Welcome!

I am Shany Koren, a passionate cancer biologist unraveling the complexities of molecular oncology, kinase signaling, and chromatin biology. My work is driven by a commitment to understanding the genetic and epigenetic mechanisms underlying cancer progression and leveraging these insights to develop innovative therapeutic strategies.

My research has revealed how hyperactive PI3-kinase signaling reprograms breast cancer cells into a stem-like state in vivo, fueling tumor heterogeneity (FMI, Switzerland), and how kinase-driven pathways converge on chromatin remodelers to regulate transcriptional programs (Princeton University/DFCI). By integrating these perspectives, I seek to define how cellular signaling reshapes the chromatin landscape to drive malignancy. Currently, as a Sidney Farber Scholar/Instructor at Dana-Farber Cancer Institute and Harvard Medical School, I am advancing this mission to uncover therapeutic opportunities at the interface of signaling and epigenetic regulation.